Hydroquinone impairs trophoblast migration and invasion via AHR-twist-IFITM1 axis.

ABSTRACT:

Introduction

Embryo implantation is a tightly regulated process, critical for a successful pregnancy. After attachment of the blastocyst to the surface epithelium of the endometrium trophoblast migrate from the trophectoderm and invade into the stromal component of endometrium. Alterations on either process will lead to implantation failure or miscarriage. Volatile organic compounds (VOCs) such as benzene induce pregnancy complications, including preterm birth and miscarriages. The mechanism of this effect is unknown. The objective of this study was to elucidate the impact of benzene metabolite, Hydroquinone, on trophoblast function. We tested the hypothesis that Hydroquinone activates the Aryl hydrocarbon receptor (AhR) pathway modulating trophoblast migration and invasion.

Met

SUBMITTER: Maxwell A 

PROVIDER: S-EPMC11421844 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature