Exogenous interactome analysis of bovine viral diarrhea virus-host using network based-approach and identification of hub genes and important pathways involved in virus pathogenesis.

ABSTRACT: Bovine viral diarrhea (BVD) is one of the most important diseases in livestock, caused by BVD virus (BVDV). During the pathogenesis of the virus, many interactions occur between host and viral proteins. Studying these interactions can help better understand the pathogenesis of the virus, identify putative functional proteins, and find new treatment and prevention strategies. To this aim, a BVDV-host protein-protein interaction (PPI) network map was constructed using Cytoscape and analyzed with cytoHubba, Kyoto Encyclopedia of Genes and Genomics (KEGG), Gene Ontology (GO), and Protein Analysis Through Evolutionary Relationships (PANTHER). N_pro with 125 connections had the greatest number of interactions with host proteins. CD46, EEF-2, and TXN genes were dete

SUBMITTER: Rezatofighi SE 

PROVIDER: S-EPMC11421936 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature