A conserved germline-specific Dsn1 alternative splice isoform supports oocyte and embryo development.

ABSTRACT: The chromosome segregation and cell division programs associated with somatic mitosis and germline meiosis display dramatic differences such as kinetochore orientation, cohesin removal, or the presence of a gap phase.^1,2,3,4,5,6 These changes in chromosome segregation require alterations to the established cell division machinery.^5,6 It remains unclear what aspects of kinetochore function and its regulatory control differ between the mitotic and meiotic cell divisions to rewire these core processes. Alternative RNA splicing can generate distinct protein isoforms to allow for the differential control of cell processes across cell types. Ho

SUBMITTER: Ly J 

PROVIDER: S-EPMC11421959 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature