Newborn adiposity is associated with cord blood DNA methylation at IGF1R and KLF7.

ABSTRACT:

Objective

This study aimed to identify whether cord blood DNA methylation at specific loci is associated with neonatal adiposity, a key risk factor for childhood obesity.

Methods

An epigenome-wide association study was conducted using the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study as a discovery sample. Linear regression models adjusted for maternal and offspring covariates and cell counts were used to analyze associations between neonatal adiposity as measured by sum of three skinfold thicknesses and cord blood DNA methylation. Assays were performed with Illumina EPIC arrays (791,359 CpG sites after quality control). Replication was performed in an independent cohort, Genetics of Glucose regulation in Gestation and Growth (Gen3G).

Results

In 2740 HAPO s

SUBMITTER: Josefson JL 

PROVIDER: S-EPMC11421971 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature