High-Density, Conformable Conducting Polymer-Based Implantable Neural Probes for the Developing Brain.

ABSTRACT: Neurologic and neuropsychiatric disorders substantially impact the pediatric population, but there is a lack of dedicated devices for monitoring the developing brain in animal models, leading to gaps in mechanistic understanding of how brain functions emerge and their disruption in disease states. Due to the small size, fragility, and high water content of immature neural tissue, as well as the absence of a hardened skull to mechanically support rigid devices, conventional neural interface devices are poorly suited to acquire brain signals without inducing damage. Here, the authors design conformable, implantable, conducting polymer-based probes (NeuroShanks) for precise targeting in the developing mouse brain without the need for skull-attached, rigid mechanical support structures. These

SUBMITTER: Ma L 

PROVIDER: S-EPMC11421980 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature