Percutaneous or surgical LAAO for stroke prevention in patients with atrial fibrillation: A network meta-analysis.

ABSTRACT:

Background

Stroke, which is mainly caused by thrombus formation in the left atrial appendage, represents the most prevalent complication of atrial fibrillation (AF). Both percutaneous left atrial appendage occlusion (p-LAAO) and surgical LAAO (s-LAAO) are used to treat AF and prevent stroke events. However, no head-to-head randomized controlled trials (RCTs) compared these strategies.

Objective

To examine the efficacy and safety of diverse strategies for reducing stroke risk using a network meta-analysis (NMA).

Methods

PubMed, EMBASE, and Cochrane repositories were explored to identify RCTs involving p-LAAO or s-LAAO, and five were included for NMA. This investigation adhered to the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-a

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC11421997 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature