Prognostic signature and immune landscape of 5-methylcytosine-related long non-coding RNAs in gastric cancer.

ABSTRACT:

Background

Long non-coding RNAs (lncRNAs) have been demonstrated to be useful in assessing the prognosis of cancer patients. However, few studies have focused on 5-methylcytosine-related lncRNAs (m5C-lncRNAs) in gastric cancer (GC). In this study, we aimed to establish a m5C-lncRNAs prognostic signature (m5C-LPS) and explore its potential impact on guiding clinical practice for GC.

Methods

RNA-sequence and clinicopathological data were retrieved from The Cancer Genome Atlas (TCGA) database, while the coexpression of long non-coding RNAs (lncRNAs) was determined using Pearson's correlation analysis. A m5C-LPS model was constructed using univariate and Lasso Cox regression, and its prognostic value and accuracy were subsequently validated. Subsequently, the expression of 11 m5

SUBMITTER: Song Q 

PROVIDER: S-EPMC11422048 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature