The influence of spatial distribution and transcriptional regulation of secondary metabolites on the bioactivities of Adenophora triphylla (Japanese lady bell).

ABSTRACT: The distribution of secondary metabolites in plant tissues plays a crucial role in determining their pharmacological properties. In this study, we investigated the dynamics of the bioactive compounds in Adenophora triphylla, a medicinal herb with diverse therapeutic applications. The anti-inflammatory properties of the EtOAc fraction from the aerial part extract (A_ EtF) exhibited an IC₅₀ value of 27.2 ± 2.3 μg/mL, significantly surpassing that of the EtOAc fraction from the root extract (R_EtF) with an IC₅₀ of 38.9 ± 2.9 μg/mL. Similarly, the anti-melanogenic activity of A_EtF (IC₅₀ = 68.9 ± 2.3 μg/mL) outperformed that of R_EtF (IC₅₀ = 90.0 ± 5.5 μg/mL). Analysis of the distinct chemical profiles of these tissues using UPLC-ESI-Q-TOF-MS

SUBMITTER: Yoon SY 

PROVIDER: S-EPMC11422053 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature