Causality investigation among gut microbiota, immune cells, and prostate diseases: a Mendelian randomization study.

ABSTRACT:

Background

The gut microbiota has been demonstrated to have a significant role in the pathogenesis and progression of a variety of diseases, including prostate cancer, prostatitis, and benign prostatic hyperplasia. Potential links between prostate diseases, immune cells and the gut microbiota have not been adequately investigated.

Methods

MR studies were conducted to estimate the effects of instrumental variables obtained from genome-wide association studies (GWASs) of 196 gut microbial taxa and 731 immune cells on the risk of prostate diseases. The primary method for analysing causal relationships was inverse variance-weighted (IVW) analysis, and the MR results were validated through various sensitivity analyses.

Results

MR analysis revealed that 28 gut microbiome ta

SUBMITTER: Yue SY 

PROVIDER: S-EPMC11422081 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature