Association between haptoglobin polymorphism and coronary artery disease: a meta-analysis.

ABSTRACT:

Background

Previous studies have investigated the association between the haptoglobin rs72294371 polymorphism and coronary artery disease (CAD) risk, but the results are controversial and uncertain. Therefore, this study aimed to systematically review the literature on haptoglobin polymorphism and susceptibility to CAD.

Methods

PubMed, Embase, Web of Science, Cochrane Library, and Wanfang databases were used to identify relevant studies from their inception to April 2024. The pooled odds ratio (OR) with corresponding 95% confidence interval (CI) were used to assess the strength of the association. An OR value greater than one suggested an increased risk; otherwise, it suggested a protective risk.

Results

A total of 15 studies comprising 8,632 individuals (2,988 cases

SUBMITTER: Wang J 

PROVIDER: S-EPMC11422136 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature