Effect of intestinal microbiota transplantation on chronic hepatitis B virus infection associated liver disease.

ABSTRACT:

Background

Research on the effects of intestinal microbiota transplantation (IMT) on chronic HBV infection (CHB) progression associated liver disease (HBV-CLD) and alterations in the microbiota post-IMT are quite limited for the moment.

Methods

By integrating microbiome with metabolome analyses, we aimed to the function of IMT and the alterations of gut microbiota in patients with HBV-CLD. First, this study included 20 patients with HBV-CLD and ten healthy controls. Then, 16 patients with CHB were given IMT with donor feces (heterologous) via oral capsule. Fecal samples from CHB patients were obtained before and after IMT, as well as healthy controls, for 16S rDNA sequencing and untargeted metabolomics analysis.

Results

The proalbuminemia were significantly increased

SUBMITTER: Deng L 

PROVIDER: S-EPMC11422146 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature