Autoantibody profiling of patients with immune checkpoint inhibitor-associated myocarditis: a pilot study.

ABSTRACT:

Background

Immune checkpoint inhibitor (ICI)-associated myocarditis is a rare, but potentially fatal, immune-related adverse event. Hence, identifying biomarkers is critical for selecting and managing patients receiving ICI treatment. Serum autoantibodies (AAbs) in patients with ICI myocarditis may serve as potential biomarkers for predicting, diagnosing, and prognosing ICI myocarditis. We conducted a pilot study using a human proteome microarray with approximately 17,000 unique full-length human proteins to investigate AAbs associated with ICI myocarditis.

Methods and results

AAb profiling was performed using sera collected from three patients with ICI myocarditis before the start of ICI treatment and immediately after myocarditis onset. All patients received anti-programme

SUBMITTER: Li S 

PROVIDER: S-EPMC11422215 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature