Genetic landscape of ESBL producing international clone ST410 of <i>Escherichia coli</i> from pediatric infections in Shenzhen, China.

ABSTRACT:

Background

The emergence of ESBLs producing cephalosporin-resistant Escherichia coli isolates poses a threat to public health. This study aims to decipher the genetic landscape and gain insights into ESBL-producing E. coli strains belonging to the high-risk clone ST410 from pediatric patients.

Methods

29 E. coli ST410 isolates were collected from young children and subjected to antimicrobial susceptibility testing, Whole-genome sequencing (WGS), serotype analysis, MLST, ESBL genes, virulence genes, and plasmid profiling.

Results

Antimicrobial susceptibility testing demonstrated a high level of resistance to cephalosporins followed by aminoglycoside, sulfonamide, carbapenem and penicillin group of antibiotics. However, n=20/29 shows MDR phenotype.

SUBMITTER: Patil S 

PROVIDER: S-EPMC11422233 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature