Alterations in the plasma proteome persist ten months after recovery from mild to moderate SARS-CoV-2 infection.

ABSTRACT:

Background

Limited data are available describing the effects of SARS-CoV-2 breakthrough infections on the plasma proteome.

Methods

PCR-positive SARS-CoV-2 patients, enrolled in a natural history study, underwent analysis of the plasma proteome. A prospective cohort of 66 unvaccinated and 24 vaccinated persons with different degrees of infection severity were evaluated acutely (within 40 days of symptom onset), and at three and ten months. Comparisons based on vaccination status alone and unsupervised hierarchical clustering were performed. A second cohort of vaccinated Omicron patients were evaluated acutely and at ten months.

Results

Acutely, unvaccinated patients manifested overexpression of proteins involved in immune and inflammatory responses, while vaccinated pa

SUBMITTER: Huapaya JA 

PROVIDER: S-EPMC11422241 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature