Over Activation of IL-6/STAT3 Signaling Pathway in Juvenile Dermatomyositis.

ABSTRACT:

Introduction

Juvenile dermatomyositis (JDM) is characterized by persistent non-purulent inflammation in the muscle and skin. The underlying mechanisms still remain uncertain. This study aims to elucidate the mechanism of interleukin-6 (IL-6) activation of Janus kinase/signal transducer and activator of transcription 3 pathway (JAK/STAT3), contributing to the pathogenesis of JDM.

Methods

Serum IL-6 levels were compared between 72 newly diagnosed patients with JDM and the same patient cohort in treatment remission. Single-cell RNA sequencing (scRNA-seq) was employed to identify differential signaling pathway expression in muscle biopsy samples from two patients with JDM and healthy controls. Immunohistochemistry was used to examine differences in STAT3 phosphorylation between

SUBMITTER: Zheng Q 

PROVIDER: S-EPMC11422336 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature