Prognostic Factors and Epidemiology of Amyotrophic Lateral Sclerosis in Southeastern United States.

ABSTRACT:

Objective

To assess the performance of known survival predictors and evaluate their stratification capability in patients with amyotrophic lateral sclerosis (ALS).

Patients and methods

We analyzed demographic and clinical variables collected at the Mayo Clinic, Florida ALS center during the first clinical visit of 1442 (100%) patients with ALS.

Results

Our cohort had a median (interquartile range [IQR]) age at diagnosis of 64.8 (57-72) years; 1350 (92%) were non-Hispanic White; and 771 (53.5%) were male. The median (IQR) diagnostic delay was 10.1 (6-18) months, body mass index was 25.4 (23-49), and forced vital capacity was 72% (52%-87%). Approximately 12% of patients tested carried a pathologic C9orf72 hexanucleotide repeat expansion. Median (IQR) ALS function

SUBMITTER: Engelberg-Cook E 

PROVIDER: S-EPMC11422511 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature