Rhodoquinone-dependent electron transport chain is essential for Caenorhabditis elegans survival in hydrogen sulfide environments.

ABSTRACT: Hydrogen sulfide (H₂S) has traditionally been considered an environmental toxin for animal lineages; yet, it plays a signaling role in various processes at low concentrations. Mechanisms controlling H₂S in animals, especially in sulfide-rich environments, are not fully understood. The main detoxification pathway involves the conversion of H₂S into less harmful forms, through a mitochondrial oxidation pathway. The first step of this pathway oxidizes sulfide and reduces ubiquinone (UQ) through sulfide-quinone oxidoreductase (SQRD/SQOR). Because H₂S inhibits cytochrome oxidase and hence UQ regeneration, this pathway becomes compromised at high H₂S concentrations. The free-living nematode Caenorhabditis elegans feeds on bacteria and can fa

SUBMITTER: Romanelli-Cedrez L 

PROVIDER: S-EPMC11422605 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature