A novel miniaturized roller pump circuit for simulation of extracorporeal circulation.

ABSTRACT:

Objectives

Extracorporeal circulation induces pronounced effects on haemostasis and rheology. To study these, an ex vivo simulation model is an attractive alternative but often requires large amounts of blood. We sought to create a miniaturized roller pump circuit requiring minimal amounts of blood and to test if the circuit could be used to compare coagulation, platelet function and blood rheology between a dextran-based and a crystalloid-based priming solution.

Methods

A miniaturized roller pump circuit requiring only 27 ml of blood was created. Blood samples from 8 cardiac surgery patients were mixed with either a dextran-based or a crystalloid-based solution and circulated for 60 min. Coagulation was assessed by rotational thromboelastometry, and platelet function by imp

SUBMITTER: Hjarpe AK 

PROVIDER: S-EPMC11422619 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature