Identification of circulating metabolites linked to the risk of breast cancer: a mendelian randomization study.

ABSTRACT:

Objective

This study aimed to investigate potential causal relationships between circulating metabolites and breast cancer risk using Mendelian randomization (MR) analysis.

Materials and methods

Summary-level genome-wide association study (GWAS) datasets for 249 circulating metabolites were obtained from the UK Biobank. GWAS datasets for estrogen receptor-positive (ER+) and estrogen receptor-negative (ER-) breast cancer were acquired from previous studies based on the Combined Oncoarray. Instrumental variables (IVs) were selected from single nucleotide polymorphisms (SNPs) associated with circulating metabolites, and MR analyses were conducted using the inverse-variance weighted (IVW) method as the primary analysis, with additional sensitivity analyses using other MR methods

SUBMITTER: Zhu X 

PROVIDER: S-EPMC11422656 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature