Splenectomy as a Risk Factor for Graft Rejection Following Endothelial Transplantation: Retrospective Study.

ABSTRACT:

Background

Anterior chamber-associated immune deviation (ACAID) is an active immunotolerance mechanism, which is induced by placing antigen into the anterior eye chamber as long as a major surgical trauma is avoided. For this reason, ACAID may be a major contributor to the favorable immunologic outcomes in Descemet membrane endothelial keratoplasty (DMEK). Rodent models have demonstrated the importance of a functional spleen for the development of an ACAID.

Objective

This study aimed to investigate whether splenectomy leads to increased rejection rates after DMEK in humans.

Methods

A retrospective evaluation was conducted on the course following DMEK at the Eye Center, Medical Center, University of Freiburg, for patients with a self-reported history of splenectomy com

SUBMITTER: Kammrath Betancor P 

PROVIDER: S-EPMC11422749 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature