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Mitochondrial Transplantation Promotes Protective Effector and Memory CD4⁺ T Cell Response During Mycobacterium Tuberculosis Infection and Diminishes Exhaustion and Senescence in Elderly CD4⁺ T cells.

ABSTRACT: Tuberculosis (TB), caused by Mycobacterium tuberculosis (M.tb), is a major global health concern, particularly affecting those with weakened immune systems, including the elderly. CD4⁺ T cell response is crucial for immunity against M.tb, but chronic infections and aging can lead to T cell exhaustion and senescence, worsening TB disease. Mitochondrial dysfunction, prevalent in aging and chronic diseases, disrupts cellular metabolism, increases oxidative stress, and impairs T-cell functions. This study investigates the effect of mitochondrial transplantation (mito-transfer) on CD4⁺ T cell differentiation and function in aged mouse models and human CD4⁺ T cells from elderly individuals. Mito-transfer in naïve CD4⁺ T cells is found to promote protec

SUBMITTER: Headley CA

PROVIDER: S-EPMC11423092 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature

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Mitochondrial Transplantation Promotes Protective Effector and Memory CD4⁺ T Cell Response During Mycobacterium Tuberculosis Infection and Diminishes Exhaustion and Senescence in Elderly CD4⁺ T cells.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Mitochondrial Transplantation Promotes Protective Effector and Memory CD4+ T Cell Response During Mycobacterium Tuberculosis Infection and Diminishes Exhaustion and Senescence in Elderly CD4+ T cells.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Mitochondrial Transplantation Promotes Protective Effector and Memory CD4⁺ T Cell Response During Mycobacterium Tuberculosis Infection and Diminishes Exhaustion and Senescence in Elderly CD4⁺ T cells.