Intraparticle Electron Transfer for Long-Lasting Tumor Chemodynamic Therapy.

ABSTRACT: Chemodynamic therapy (CDT) is a novel tumor treatment method by using hydroxyl radicals (^•OH) to kill cancer cells. However, its therapeutic effects are strictly confined by the short lifespan of ^•OH and reduced ^•OH generation speed. Herein, an effective CDT is achieved by both improving ^•OH lifetime and long-lasting generating ^•OH through intraparticle electron transfer within heterogeneous nanoparticles (NPs). These heterogeneous NPs are composed of evenly distributed Cu and Fe₃O₄ (CFO NPs) with large interaction interfaces, and electrons tend to transfer from Cu to Fe₃O₄ for the appearance of ≡Cu²⁺ and increase in ≡Fe²⁺. The generated ≡Cu²⁺ can interact wit

SUBMITTER: Yu J 

PROVIDER: S-EPMC11423095 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature