Common single nucleotide polymorphisms associated with idiopathic pulmonary fibrosis: a systematic review.

ABSTRACT:

Background

Several genetic variants are associated with the risk of idiopathic pulmonary fibrosis (IPF). These have not been systematically reviewed.

Methods

We searched the PubMed, Embase and GWAS Catalog databases for studies indexed between inception and 15 January 2024 describing genetic variants associated with IPF susceptibility. We included studies describing common associated single nucleotide polymorphisms (SNPs). We excluded studies describing rare variants, non-SNP variants and those without an allelic model analysis. We recorded study type, participant characteristics, genotyping methods, IPF diagnostic criteria, the SNPs and the respective genes, odds ratios, and other details. We also searched databases for functions of the identified genes.

Results

The

SUBMITTER: Dhooria S 

PROVIDER: S-EPMC11423133 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature