An Integrated Optogenetic and Bioelectronic Platform for Regulating Cardiomyocyte Function.

ABSTRACT: Bioelectronic medicine is emerging as a powerful approach for restoring lost endogenous functions and addressing life-altering maladies such as cardiac disorders. Systems that incorporate both modulation of cellular function and recording capabilities can enhance the utility of these approaches and their customization to the needs of each patient. Here we report an integrated optogenetic and bioelectronic platform for stable and long-term stimulation and monitoring of cardiomyocyte function in vitro. Optical inputs are achieved through the expression of a photoactivatable adenylyl cyclase, that when irradiated with blue light causes a dose-dependent and time-limited increase in the secondary messenger cyclic adenosine monophosphate with subsequent rise in autonomous cardiomyocyte beating r

SUBMITTER: Bolonduro OA 

PROVIDER: S-EPMC11423186 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature