Isoliquiritigenin ameliorates abnormal oligodendrocyte development and behavior disorders induced by white matter injury.

ABSTRACT:

Background

White matter injury is a predominant form of brain injury in preterm infants. However, effective drugs for its treatment are currently lacking. Previous studies have shown the neuroprotective effects of Isoliquiritigenin (ISL), but its impact on white matter injury in preterm infants remains poorly understood.

Aims

This study aimed to investigate the protective effects of ISL against white matter injury caused by infection in preterm infants using a mouse model of lipopolysaccharide-induced white matter injury, integrating network pharmacology as well as in vivo and in vitro experiments.

Methods

This study explores the potential mechanisms of ISL on white matter injury by integrating network pharmacology. Core pathways and biological processes

SUBMITTER: Wu D 

PROVIDER: S-EPMC11423201 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature