Supramolecular Nano-Tracker for Real-Time Tracking of Drug Release and Efficient Combination Therapy.

ABSTRACT: Real-time tracking of drug release from nanomedicine in vivo is crucial for optimizing its therapeutic efficacy in clinical settings, particularly in dosage control and determining the optimal therapeutic window. However, most current real-time tracking systems require a tedious synthesis and purification process. Herein, a supramolecular nano-tracker (SNT) capable of real-time tracking of drug release in vivo based on non-covalent host-guest interactions is presented. By integrating multiple cavities into a single nanoparticle, SNT achieves co-loading of drugs and probes while efficiently quenching the photophysical properties of the probe through host-guest complexation. Moreover, SNT is readily degraded under hypoxic tumor tissues, leading to the simultaneous release of drugs and probes

SUBMITTER: Chen X 

PROVIDER: S-EPMC11423228 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature