Targeting α₁- and α₂-adrenergic receptors as a countermeasure for fentanyl-induced locomotor and ventilatory depression.

ABSTRACT: This study assessed the ability of α₁ and α₂-adrenergic drugs to decrease fentanyl-induced locomotor and ventilatory depression. Rats were given saline or fentanyl, followed by: (1) naltrexone, (2) naloxone, (3) nalmefene, (4) α₁ agonist phenylephrine, (5) α₁ antagonist prazosin, (6) α_1D antagonist BMY-7378, (7) α₂ agonist clonidine, (8) α₂ antagonist yohimbine or (9) vehicle. All µ-opioid antagonists dose-dependently reversed fentanyl-induced locomotor and ventilatory depression. While the α₁ drugs did not alter the effects of fentanyl, clonidine dose-dependently decreased locomotion and respiration with and without fentanyl. Conversely, yohimbine given at a low dose (0.3-1 mg/kg) stimulated ventilatio

SUBMITTER: Shaykin JD 

PROVIDER: S-EPMC11423298 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature