Metal-free Borylation of α-Naphthamides and Phenylacetic Acid Drug.

ABSTRACT: Site-selective C-H borylation is an important strategy for constructing molecular diversity in arenes and heteroarenes. Although transition-metal-catalyzed borylation is well explored, developing metal-free strategies remains scarce. Herein, we developed a straightforward approach for BBr₃-mediated selective C-H borylation of naphthamide and phenyl acetamide derivatives under metal-free conditions. This methodology appears to be economical and cost-effective. Successful borylation of drug molecules such as ibuprofen and indoprofen demonstrates the versatility and utility of this metal-free borylation. An exclusive monoselectivity was observed without a trace of diboration. Despite the possibility of forming a 5-membered boronated intermediate at the ortho-position, the se

SUBMITTER: Maji S 

PROVIDER: S-EPMC11423307 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature