Proteomic exploration of potential blood biomarkers in haemophilic arthropathy.

ABSTRACT:

Background and aims

The pathophysiology of haemophilic arthropathy (HA) is complex and largely undefined. Proteomic analyses provide insights into the intricate mechanisms of the HA.Our study aimed to identify differentially expressed proteins in relation to the severity of HA, explore their pathophysiological roles, and evaluate their potential as HA biomarkers.

Methods

Our cross-sectional observational study encompassed 30 HA patients and 15 healthy subjects. Plasma samples were pooled into three groups of 15 samples from those with severe haemophilic arthropathy (sHA), mild haemophilic arthropathy (mHA) and healthy controls. Proteomic analysis was performed using liquid chromatography-mass spectrometry. The severity of HA was assessed using the World Federation of Haemoph

SUBMITTER: Kalebota N 

PROVIDER: S-EPMC11423339 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature