PhageGE: an interactive web platform for exploratory analysis and visualization of bacteriophage genomes.

ABSTRACT:

Background

Antimicrobial resistance is a serious threat to global health. Due to the stagnant antibiotic discovery pipeline, bacteriophages (phages) have been proposed as an alternative therapy for the treatment of infections caused by multidrug-resistant pathogens. Genomic features play an important role in phage pharmacology. However, our knowledge of phage genomics is sparse, and the use of existing bioinformatic pipelines and tools requires considerable bioinformatic expertise. These challenges have substantially limited the clinical translation of phage therapy.

Findings

We have developed PhageGE (Phage Genome Explorer), a user-friendly graphical interface application for the interactive analysis of phage genomes. PhageGE enables users to perform key analyses, including

SUBMITTER: Zhao J 

PROVIDER: S-EPMC11423353 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature