In-Depth Mass Spectrometry Study of Vanadium(IV) Complexes with Model Peptides.

ABSTRACT: Investigating the speciation of vanadium complexes in the presence of potential biomolecular targets under physiological conditions remains challenging, and further experimental techniques are needed to better understand the mechanism of action of potential metallodrugs. The interaction of two model peptides (angiotensin I and angiotensin II) with three well-known oxidovanadium(IV) compounds with antidiabetic and/or anticancer activity, [V^IVO(pic)₂(H₂O)], [V^IVO(ma)₂], and [V^IVO(dhp)₂] (where pic, ma, and dhp are picolinate, maltolate, and 1,2-dimethyl-3-hydroxy-4(1H)-pyridinonate anions, respectively), was investigated by ESI-MS/MS (electrospray ionization tandem mass spectrometry) and complemented by EPR (electro

SUBMITTER: Kussner K 

PROVIDER: S-EPMC11423397 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature