Metabolic profiling of MRI-measured liver fat in the UK Biobank.

ABSTRACT:

Objective

Liver fat associates with obesity-related metabolic disturbances and may precede incident diseases. Metabolomic profiles of liver fat in the UK Biobank were investigated.

Methods

Regression models assessed the associations between 180 metabolites and proton density liver fat fraction (PDFF) measured 5 years later through magnetic resonance imaging, as the difference (in SD units) of each log metabolite measure with 1-SD higher PDFF among those without chronic disease and not taking statins, and by diabetes and cardiovascular diseases.

Results

After accounting for confounders, multiple metabolites were associated positively with liver fat (p < 0.0001 for 152 traits), particularly extremely large and very large lipoprotein particle concentrations, very low-den

SUBMITTER: Gnatiuc Friedrichs L 

PROVIDER: S-EPMC11423419 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature