Effects of fecal microbiota transplantation on clinical outcomes and fecal microbiota of foals with diarrhea.

ABSTRACT:

Background

Diarrhea in foals can be associated with disruption of the intestinal microbiota (dysbiosis). Effective management of intestinal dysbiosis in foals has not been demonstrated.

Hypothesis/objectives

Fecal microbiota transplantation (FMT) in foals with diarrhea influences the intestinal microbiota and improves clinical and clinicopathological outcomes.

Animals

Twenty-five foals <6 months of age with diarrhea and systemic inflammatory response syndrome at 3 veterinary hospitals.

Methods

A prospective randomized placebo-controlled cohort study. Foals in the FMT group (n = 19) or control group (n = 9) received FMT or electrolyte solution once daily for 3 days. Fecal samples were obtained on Day 0 (D0), D1, D2, D3, and D7. Within group and between group dat

SUBMITTER: Bell J 

PROVIDER: S-EPMC11423448 | biostudies-literature | 2024 Sep-Oct

REPOSITORIES: biostudies-literature