A prospective evaluation of succinct prednisone tapering after brain tumor irradiation in dogs.

ABSTRACT:

Background

To ameliorate anticipated or ongoing neurological deficits, dogs undergoing brain tumor irradiation often are prescribed lengthy courses of prednisone PO during and after radiotherapy (RT). This practice can contribute to unwanted corticosteroid-associated morbidity and may be unnecessary.

Objective

Determine whether long-term corticosteroid dependency can be minimized by use of succinct prednisone tapering.

Animals

Fifty-five pet dogs undergoing brain tumor irradiation.

Methods

Nineteen dogs were treated using a "rapid-taper" protocol wherein corticosteroid dose reduction began 0 to 20 days after completing RT. Outcomes were compared with a retrospectively studied control group ("slow-taper"; N = 36 dogs) in which corticosteroids were tapered more s

SUBMITTER: Strasberg JR 

PROVIDER: S-EPMC11423478 | biostudies-literature | 2024 Sep-Oct

REPOSITORIES: biostudies-literature