Time to resolution of airway inflammation caused by bronchoalveolar lavage in healthy horses.

ABSTRACT:

Background

Bronchoalveolar lavage (BAL) is a common procedure for evaluation of the equine lower airways. Time to resolution of post-BAL inflammation has not been clearly defined.

Hypothesis

Residual inflammation, evident by changes in immune cell populations and inflammatory cytokines, will resolve by 72 hours after BAL.

Animals

Six adult, healthy, institution-owned horses.

Methods

Randomized, complete cross-over design. Each horse underwent 3 paired BALs, including a baseline and then 48, 72, and 96 hours later, with a 7-day washout between paired BALs. Each sample underwent cytological evaluation and cytokine concentrations were determined by a commercially available multiplex bead immunoassay. Statistical analysis was performed by multilevel mixed-effects P

SUBMITTER: Woodrow JS 

PROVIDER: S-EPMC11423487 | biostudies-literature | 2024 Sep-Oct

REPOSITORIES: biostudies-literature