Regulatory role of the lncRNAs MIAT and PVT1 in Behcet's disease through targeting miR-93-5p and miR-124-3p.

ABSTRACT:

Background

Noncoding RNAs play pivotal roles in the process of autoimmune diseases. However, the definite contributions of these molecules to Behçet's disease (BD) are still unknown. This study aimed to explore the clinical value of a novel competing endogenous (ce) RNA network in the pathogenesis of BD and to assess its use in primary diagnosis.

Methods

Bioinformatic analysis was applied to construct a BD-related ceRNA network: lncRNA (MIAT and PVT1)-miRNA (miR-93-5p and miR-124-3p)-mRNA (SOD-2 and MICA). Blood was obtained from 70 BD patients and 30 healthy subjects, and the serum expression of the tested RNAs was estimated via quantitative real-time PCR (qPCR). Serum tumor necrosis factor-alpha (TNF-α) levels were also determined. The associations between these RNAs were

SUBMITTER: ElMonier AA 

PROVIDER: S-EPMC11423507 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature