On-treatment biopsies to predict response to neoadjuvant chemotherapy for breast cancer.

ABSTRACT:

Background

Patients with pathologic complete response (pCR) to neoadjuvant chemotherapy for invasive breast cancer (BC) have better outcomes, potentially warranting less extensive surgical and systemic treatments. Early prediction of treatment response could aid in adapting therapies.

Methods

On-treatment biopsies from 297 patients with invasive BC in three randomized, prospective neoadjuvant trials were assessed (GeparQuattro, GeparQuinto, GeparSixto). BC quantity, tumor-infiltrating lymphocytes (TILs), and the proliferation marker Ki-67 were compared to pre-treatment samples. The study investigated the correlation between residual cancer, changes in Ki-67 and TILs, and their impact on pathologic complete response (pCR) and disease-free survival (DFS).

Results

Among

SUBMITTER: Sinn BV 

PROVIDER: S-EPMC11423510 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature