Gene-variant specific effects of plasma amyloid-β levels in Swedish autosomal dominant Alzheimer disease.

ABSTRACT:

Background

Several blood-based biomarkers offer the opportunity of in vivo detection of brain pathology and neurodegeneration in Alzheimer disease with high specificity and sensitivity, but the performance of amyloid-β (Aβ) measurements remains under evaluation. Autosomal dominant Alzheimer disease (ADAD) with mutations in PSEN1, PSEN2 and APP can be studied as a model for sporadic Alzheimer disease. However, clarifying the genetic effects on the Aβ-levels in different matrices such as cerebrospinal fluid or plasma is crucial for generalizability and utility of data. We aimed to explore plasma Aβ concentrations over the Alzheimer disease continuum in a longitudinal cohort of genetic Alzheimer disease.

Methods

92 plasma samples were collected from at-risk individuals (n = 47)

SUBMITTER: Johansson C 

PROVIDER: S-EPMC11423518 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature