Electron diffraction and solid-state NMR reveal the structure and exciton coupling in a eumelanin precursor.

ABSTRACT: Eumelanin, a versatile biomaterial found throughout the animal kingdom, performs essential functions like photoprotection and radical scavenging. The diverse properties of eumelanin are attributed to its elusive and heterogenous structure with DHI (5,6-dihydroxyindole) and DHICA (5,6-dihydroxyindole-2-carboxylic acid) precursors as the main constituents. Despite DHICA being recognized as the key eumelanin precursor, its crystal structure and functional role in the assembled state remain unknown. Herein, we employ a synthesis-driven, bottom-up approach to elucidate the structure and assembly-specifics of DHICA, a critical building block of eumelanin. We introduce an interdisciplinary methodology to analyse the nanocrystalline assembly of DHICA, employing three-dimensional electron diffracti

SUBMITTER: Vinod K 

PROVIDER: S-EPMC11423530 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature