Plasma homocysteine and longitudinal change in cognitive function among urban adults.

ABSTRACT:

Background

Cross-sectional and longitudinal studies have inconsistently linked cognitive performance and change over time to an elevated level of homocysteine (Hcy), with few conducted among urban adults.

Methods

Longitudinal data [Visit 1 (2004-2009) and Visit 2 (2009-2013)] were analyzed from up to 1430 selected Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) participants. Baseline and follow-up blood Hcy was measured, while 11 cognitive function test scores were assessed at either of these two visits. Overall, sex- and race-stratified associations were evaluated using mixed-effects linear regression models, adjusting for key potential confounders. Interaction effects between Hcy and serum levels of folate and vitamin B-12 were also tested.

Res

SUBMITTER: Beydoun MA 

PROVIDER: S-EPMC11423561 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature