Impact of organic compounds on the stability of influenza A virus in deposited 1-μL droplets.

ABSTRACT: The composition of respiratory fluids influences the stability of viruses in exhaled aerosol particles and droplets, though the role of respiratory organics in modulating virus stability remains poorly understood. This study investigates the effect of organic compounds on the stability of influenza A virus (IAV) in deposited droplets. We compare the infectivity loss of IAV at different relative humidities (RHs) over the course of 1 h in 1-µL droplets consisting of phosphate-buffered saline (without organics), synthetic lung fluid, or nasal mucus (both containing organics). We show that IAV stability increases with increasing organic:salt ratios. Among the various organic species, proteins are identified as the most protective component, with smaller proteins stabilizing IAV more efficientl

SUBMITTER: Schaub A 

PROVIDER: S-EPMC11423574 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature