Concurrent Ascaris infection modulates host immunity resulting in impaired control of Salmonella infection in pigs.

ABSTRACT: Ascaris is one of the most widespread helminth infections, leading to chronic morbidity in humans and considerable economic losses in pig farming. In addition, pigs are an important reservoir for the zoonotic salmonellosis, where pigs can serve as asymptomatic carriers. Here, we investigated the impact of an ongoing Ascaris infection on the immune response to Salmonella in pigs. We observed higher bacterial burdens in experimentally coinfected pigs compared to pigs infected with Salmonella alone. The impaired control of Salmonella in the coinfected pigs was associated with repressed interferon gamma responses in the small intestine and with the alternative activation of gut macrophages evident in elevated CD206 expression. Ascaris single and

SUBMITTER: Midha A 

PROVIDER: S-EPMC11423588 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature