Novel epigenetic biomarkers for hematopoietic cancer found in twins.

ABSTRACT:

Background and purpose

This article aims to identify epigenetic markers and detect early development of hematopoietic malignancies through an epigenome wide association study of DNA methylation data.

Materials and methods

This register-based study includes 1,085 Danish twins with 31 hematopoietic malignancies and methylation levels from 450,154 5'-C-phospate-G-3' (CpG) sites. Associations between methylation levels and incidence of hematopoietic malignancy is studied through time-to-event regression. The matched case-cotwin design, where one twin has a malignancy and the cotwin does not, is applied to enhance control for unmeasured shared confounding and false discoveries. Predictive performance is validated in the independent Older Finnish Twin Cohort.

Results and interp

SUBMITTER: Clemmensen SB 

PROVIDER: S-EPMC11423697 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature