Alterations in anterior lens capsule structure and LTBP-2 expression in primary angle-closure glaucoma.

ABSTRACT:

Objective

This study investigated the role of latent-transforming growth factor β-binding protein 2 (LTBP-2) in primary angle-closure glaucoma (PACG) by analysing its expression and the ultrastructure of the anterior lens capsule in PACG patients with age-related cataract (ARC).

Methods

Tissue samples of the anterior lens capsule were collected from patients undergoing cataract phacoemulsification surgery. Patients in the experimental group were diagnosed with primary angle-closure (PAC) combined with ARC (PAC+ARC) and PACG combined with ARC (PACG+ARC). The control group consisted of patients with only ARC. The techniques used included scanning electron microscopy, real-time fluorescence quantitative polymerase chain reaction (RT-qPCR), western blotting and immunofluorescenc

SUBMITTER: Tian X 

PROVIDER: S-EPMC11423727 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature