Alginate-based artificial antigen presenting cells expand functional CD8⁺ T cells with memory characteristics for adoptive cell therapy.

ABSTRACT: The development of artificial Antigen Presenting Cells (aAPCs) has led to improvements in adoptive T cell therapy (ACT), an immunotherapy, for cancer treatment. aAPCs help to streamline the consistent production and expansion of T cells, thus reducing the time and costs associated with ACT. However, several issues still exist with ACT, such as insufficient T cell potency, which diminishes the translational potential for ACT. While aAPCs have been used primarily to increase production efficiency of T cells for ACT, the intrinsic properties of a biomaterial-based aAPC may affect T cell phenotype and function. In CD8⁺ T cells, reactive oxygen species (ROS) and oxidative stress accumulation can activate Forkhead box protein O1 (FOXO1) to transcribe antioxidants which reduce ROS and

SUBMITTER: Omotoso MO 

PROVIDER: S-EPMC11423771 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature