Computational modeling establishes mechanotransduction as a potent modulator of the mammalian circadian clock.

ABSTRACT: Mechanotransduction, which is the integration of mechanical signals from the external environment of a cell to changes in intracellular signaling, governs many cellular functions. Recent studies have shown that the mechanical state of the cell is also coupled to the cellular circadian clock. To investigate possible interactions between circadian rhythms and cellular mechanotransduction, we have developed a computational model that integrates the two pathways. We postulated that translocation of the transcriptional regulators MRTF (herein referring to both MRTF-A and MRTF-B), YAP and TAZ (also known as YAP1 and WWTR1, respectively; collectively denoted YAP/TAZ) into the nucleus leads to altered expression of circadian proteins. Simulations from our model predict that lower levels of cytoske

SUBMITTER: Francis EA 

PROVIDER: S-EPMC11423814 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature