Simultaneous inference of selection and population growth from patterns of variation in the human genome.

ABSTRACT: Natural selection and demographic forces can have similar effects on patterns of DNA polymorphism. Therefore, to infer selection from samples of DNA sequences, one must simultaneously account for demographic effects. Here we take a model-based approach to this problem by developing predictions for patterns of polymorphism in the presence of both population size change and natural selection. If data are available from different functional classes of variation, and a priori information suggests that mutations in one of those classes are selectively neutral, then the putatively neutral class can be used to infer demographic parameters, and inferences regarding selection on other classes can be performed given demographic parameter estimates. This procedure is more robust to assumptions regard

SUBMITTER: Williamson SH 

PROVIDER: S-EPMC1142382 | biostudies-literature | 2005 May

REPOSITORIES: biostudies-literature