OPOSSUM: identification of over-represented transcription factor binding sites in co-expressed genes.

ABSTRACT: Targeted transcript profiling studies can identify sets of co-expressed genes; however, identification of the underlying functional mechanism(s) is a significant challenge. Established methods for the analysis of gene annotations, particularly those based on the Gene Ontology, can identify functional linkages between genes. Similar methods for the identification of over-represented transcription factor binding sites (TFBSs) have been successful in yeast, but extension to human genomics has largely proved ineffective. Creation of a system for the efficient identification of common regulatory mechanisms in a subset of co-expressed human genes promises to break a roadblock in functional genomics research. We have developed an integrated system that searches for evidence of co-regulation by on

SUBMITTER: Ho Sui SJ 

PROVIDER: S-EPMC1142402 | biostudies-literature | 2005

REPOSITORIES: biostudies-literature