Cord blood granulocyte levels are associated with severe bronchiolitis in the first year of life.

ABSTRACT:

Objectives

Bronchiolitis is a leading cause of infant hospitalisation in the first year of life, and it preferentially affects infants born to mothers with asthma. Here, we evaluate cord blood granulocytes in infants born to mothers with asthma participating in the Breathing for Life Trial (BLT), to investigate early life determinants of bronchiolitis hospitalisation within the first year of life.

Methods

Cord blood from 89 participants was collected into EDTA tubes and processed within 6 h of birth. Cells were stained in whole cord blood for eosinophils (CD45⁺, CD193⁺, CD16^-), and neutrophils (CD45⁺, CD193^-, CD16⁺). Medical records were reviewed for bronchiolitis hospitalisation in the first 12 months of life

SUBMITTER: Martins Costa Gomes G 

PROVIDER: S-EPMC11424167 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature