Mitochondrial complex I promotes kidney cancer metastasis.

ABSTRACT: Most kidney cancers are metabolically dysfunctional^1-4, but how this dysfunction affects cancer progression in humans is unknown. We infused ¹³C-labelled nutrients in over 80 patients with kidney cancer during surgical tumour resection. Labelling from [U-¹³C]glucose varies across subtypes, indicating that the kidney environment alone cannot account for all tumour metabolic reprogramming. Compared with the adjacent kidney, clear cell renal cell carcinomas (ccRCCs) display suppressed labelling of tricarboxylic acid (TCA) cycle intermediates in vivo and in ex vivo organotypic cultures, indicating that suppressed labelling is tissue intrinsic. [1,2-¹³C]acetate and [U-¹³C]glutamine infusions in patients, coupled with measurements of respira

SUBMITTER: Bezwada D 

PROVIDER: S-EPMC11424252 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature